The Duttons face a new set of challenges in the early 20th century, including the rise of Western expansion, Prohibition and the Great Depression.

Holden and the Roci face off against Marco’s forces and Drummer, while Alex and Bobbie attempt a dangerous rescue of Naomi, and the balance of power in the Solar System…

Holden and Fred deal with infiltrators on Tycho. Drummer’s past comes back to haunt her. Amos returns to Baltimore. Alex and Bobbie’s investigation on Mars leads to rogue soldiers.

Coulson and team find themselves in an epic face-off against Hydra to uncover an ancient secret, while Ward kidnaps his brother, Senator Christian Ward, for a violent trip down memory…

The world turns against S.H.I.E.L.D. when Hydra impersonates them to attack The United Nations, and an unexpected enemy leads the charge to bring about their downfall.