Sheldon’s solution to Penny’s financial difficulty leads to a confrontation between Leonard and Penny’s ex-boyfriend.

Sam and Dean investigate a brutal death and discover that the killer is a lycanthrope: a werewolf.

Margo feels the pressure of ruling; Julia’s friends question her behavior; Quentin faces the repercussions of the deal he made; Penny finds a way to help Kady.

Rick, Hershel and Glen are trapped and fight to survive; Shane finds Lori in danger.

Derek and Addison’s relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of…

Sheldon creates a scientific procedure for making friends.

A fatal automobile accident from 1992 leaves an angry apparition haunting a remote stretch of highway, and Sam and Dean try to lay it to rest.

Rick and the others try to restore order in the aftermath of a terrible discovery. Hershel takes up an old habit and disappears, Rick and Glenn must follow him into…

Derek is still operating when he finds out about Meredith’s current situation. Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and…

Penny’s criticism of Wolowitz’s romantic life pushes him into depression and AWOL for a fighting robot battle the rest of guys are depending on him for.

The Winchester brothers seek the help of their family friend Bobby while investigating a series of unexplained happenings on a local college campus.

Hershel sets a deadline. All secrets are out in the open. Glenn stands up for himself and Shane takes charge.

An explosive case arrives at the O.R. that might endanger all the lives of the people working there, which leads Dr. Burke to declare a “Code Black” for the hospital….

Penny starts dating Leonard’s handsome colleague; Leonard and his friends are tortured by Sheldon’s obsession with gift-giving etiquette.

Sam contacts Dean after being missing for a week. When they reunite, Dean finds Sam covered in blood and with no recollection of what happened.

Harvey must fire an accountant for falsifying his credentials, but Mike finds a more sinister motive for his termination and becomes concerned about his own employment. Meanwhile, Louis thinks he’s…

Pablo goes into hiding as the political tide turns against him, but he finds a way to strike back. Murphy and Peña finally get the CIA to help them.

Secrets are told and secrets are revealed. Hershel refuses to acknowledge the world’s new reality. Andrea comes out of her shell. Everyone is becoming more and more aware that “everything…

All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally joins the nurses on…

Leonard asks Penny for advice when his new relationship starts moving too fast.

An angel causes people to cheerfully go out to murder, and when the Winchesters investigate one of them falls under its sway.

Concerned for their safety, the group makes a plan – one that Hershel disagrees with adamantly. He makes it clear the group is fine to stay for now, but not…

After they escape a riot, Travis, Liza and Chris seek refuge with the Salazars; Madison defends her home.

Meredith and Cristina lie to each other and themselves about their relationships with McDreamy and Burke, respectively. George is given a hard task to expel a discharged and defiant woman…

Sheldon is thrilled when Leonard starts dating a woman who meets Sheldon’s stringent standards.

The Winchesters investigate a series of crimes where robbers with no criminal past commit suicide after the hold-ups.

Shane makes a deadly sacrifice which leads to unusual behavior and self-distancing. The rest of the group tries to hang on somewhere between living to die and dying to live.

Nathan invites Madeline and Ed to a couples’ dinner to discuss a “parenting paradigm” for Abigail. Celeste prepares for a city-council meeting about Madeline’s play, and bristles at Perry’s concerns…

Cristina is bothered by a new year’s mandatory work limit. Izzie patient, Denny Duquette, wants two things: 1. a heart transplant, 2. Izzie. Addison detests Derek’s trailer, Derek visits Meredith’s…

Leonard inadvertently steals away the new woman Wolowitz thinks is the love of his life.

Sam and Dean investigate an Connecticut inn run by a single mother where mysterious deaths are taking place. They find evidence of Hoodoo, and try to figure out who is…

The group desperately awaits Shane’s return. Shane finds himself trapped in a school, surrounded by the undead. Daryl and Andrea search for someone in the woods.

The holiday season has started but not everyone is in a festive mood. This is Alex’s last day in the hospital unless he passes his boards practical exam the next…

When Sheldon bans Penny from the apartment for numerous minor infractions, she decides to retaliate.

Sam meets a woman who shares his ability to have visions, and she warns him that she has seen the future… where he dies in an explosion.

Rick discovers a possible safe haven. Shane must go on a dangerous mission to get needed medical supplies.

Dark secrets are revealed as Coulson and his team put everything on the line to stop Garrett and the forces of Hydra. But when the dust settles, Coulson will find…

Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns…

Sheldon and the gang are confused when a young grad student is attracted to him.

Sam has a vision of Dean shooting a defenseless man, and they go to the town of River Grove, where they find the townspeople have been possessed by a virus…